AustralieFrV1, Main, Exploration, bibRecord, 002662

Utility of 18fluoro-deoxyglucose positron emission tomography for prognosis and response assessments in a phase 2 study of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma

Identifieur interne : 002662 ( Main/Exploration ); précédent : 002661; suivant : 002663

Utility of 18fluoro-deoxyglucose positron emission tomography for prognosis and response assessments in a phase 2 study of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma

Auteurs : S. Horwitz [États-Unis] ; B. Coiffier [France] ; F. Foss [États-Unis] ; H. M. Prince [Australie] ; L. Sokol [États-Unis] ; M. Greenwood [Australie] ; D. Caballero [Espagne] ; F. Morschhauser [France] ; L. Pinter-Brown ; S. P. Iyer ; A. Shustov ; J. Nichols ; J. Balser ; B. Balser ; B. Pro [États-Unis]

Source :

Annals of Oncology [ 0923-7534 ] ; 2015.

RBID : PMC:4374388

Descripteurs français

KwdFr :
- Antibiotiques antinéoplasiques (usage thérapeutique), Depsipeptides (usage thérapeutique), Fluorodésoxyglucose F18 (pharmacocinétique), Humains, Induction de rémission, Lymphome T périphérique (anatomopathologie), Lymphome T périphérique (imagerie diagnostique), Lymphome T périphérique (mortalité), Lymphome T périphérique (traitement médicamenteux), Pronostic, Radiopharmaceutiques (pharmacocinétique), Répartition dans les tissus, Résistance aux médicaments antinéoplasiques (), Stade de la tumeur, Taux de survie, Tomographie par émission de positons (utilisation), Études de suivi, Études prospectives.
MESH :
- anatomopathologie : Lymphome T périphérique.
- imagerie diagnostique : Lymphome T périphérique.
- mortalité : Lymphome T périphérique.
- pharmacocinétique : Fluorodésoxyglucose F18, Radiopharmaceutiques.
- traitement médicamenteux : Lymphome T périphérique.
- usage thérapeutique : Antibiotiques antinéoplasiques, Depsipeptides.
- utilisation : Tomographie par émission de positons.
- Humains, Induction de rémission, Pronostic, Répartition dans les tissus, Résistance aux médicaments antinéoplasiques, Stade de la tumeur, Taux de survie, Études de suivi, Études prospectives.

English descriptors

KwdEn :
- Antibiotics, Antineoplastic (therapeutic use), Depsipeptides (therapeutic use), Drug Resistance, Neoplasm (drug effects), Fluorodeoxyglucose F18 (pharmacokinetics), Follow-Up Studies, Humans, Lymphoma, T-Cell, Peripheral (diagnostic imaging), Lymphoma, T-Cell, Peripheral (drug therapy), Lymphoma, T-Cell, Peripheral (mortality), Lymphoma, T-Cell, Peripheral (pathology), Neoplasm Staging, Positron-Emission Tomography (utilization), Prognosis, Prospective Studies, Radiopharmaceuticals (pharmacokinetics), Remission Induction, Survival Rate, Tissue Distribution.
MESH :
- chemical , pharmacokinetics : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- chemical , therapeutic use : Antibiotics, Antineoplastic, Depsipeptides.
- diagnostic imaging : Lymphoma, T-Cell, Peripheral.
- drug effects : Drug Resistance, Neoplasm.
- drug therapy : Lymphoma, T-Cell, Peripheral.
- mortality : Lymphoma, T-Cell, Peripheral.
- pathology : Lymphoma, T-Cell, Peripheral.
- utilization : Positron-Emission Tomography.
- Follow-Up Studies, Humans, Neoplasm Staging, Prognosis, Prospective Studies, Remission Induction, Survival Rate, Tissue Distribution.

Abstract

This study examined the utility of PET scans for assessing prognosis and response to treatment in patients with relapsed/refractory PTCL receiving romidepsin. For patients with stable disease or partial response by conventional criteria, PET status better differentiated durability of response than conventional response category. Routine PET use may aid in treatment planning in patients with PTCL.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374388

DOI: 10.1093/annonc/mdv010
PubMed: 25605745
PubMed Central: 4374388

Affiliations:

Australie, Espagne, France, États-Unis

Le document en format XML

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fluoro-deoxyglucose positron emission tomography for prognosis and response assessments in a phase 2 study of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma</title>
<author><name sortKey="Horwitz, S" sort="Horwitz, S" uniqKey="Horwitz S" first="S." last="Horwitz">S. Horwitz</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Coiffier, B" sort="Coiffier, B" uniqKey="Coiffier B" first="B." last="Coiffier">B. Coiffier</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Utility of <sup>18</sup>
fluoro-deoxyglucose positron emission tomography for prognosis and response assessments in a phase 2 study of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma</title>
<author><name sortKey="Horwitz, S" sort="Horwitz, S" uniqKey="Horwitz S" first="S." last="Horwitz">S. Horwitz</name>
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<author><name sortKey="Caballero, D" sort="Caballero, D" uniqKey="Caballero D" first="D." last="Caballero">D. Caballero</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Morschhauser, F" sort="Morschhauser, F" uniqKey="Morschhauser F" first="F." last="Morschhauser">F. Morschhauser</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Pinter Brown, L" sort="Pinter Brown, L" uniqKey="Pinter Brown L" first="L." last="Pinter-Brown">L. Pinter-Brown</name>
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</nlm:aff>
</affiliation>
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<author><name sortKey="Iyer, S P" sort="Iyer, S P" uniqKey="Iyer S" first="S. P." last="Iyer">S. P. Iyer</name>
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</nlm:aff>
</affiliation>
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,<addr-line>Seattle</addr-line>
</nlm:aff>
</affiliation>
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<author><name sortKey="Balser, J" sort="Balser, J" uniqKey="Balser J" first="J." last="Balser">J. Balser</name>
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</nlm:aff>
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<author><name sortKey="Pro, B" sort="Pro, B" uniqKey="Pro B" first="B." last="Pro">B. Pro</name>
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<term>Depsipeptides (therapeutic use)</term>
<term>Drug Resistance, Neoplasm (drug effects)</term>
<term>Fluorodeoxyglucose F18 (pharmacokinetics)</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Lymphoma, T-Cell, Peripheral (diagnostic imaging)</term>
<term>Lymphoma, T-Cell, Peripheral (drug therapy)</term>
<term>Lymphoma, T-Cell, Peripheral (mortality)</term>
<term>Lymphoma, T-Cell, Peripheral (pathology)</term>
<term>Neoplasm Staging</term>
<term>Positron-Emission Tomography (utilization)</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Radiopharmaceuticals (pharmacokinetics)</term>
<term>Remission Induction</term>
<term>Survival Rate</term>
<term>Tissue Distribution</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antibiotiques antinéoplasiques (usage thérapeutique)</term>
<term>Depsipeptides (usage thérapeutique)</term>
<term>Fluorodésoxyglucose F18 (pharmacocinétique)</term>
<term>Humains</term>
<term>Induction de rémission</term>
<term>Lymphome T périphérique (anatomopathologie)</term>
<term>Lymphome T périphérique (imagerie diagnostique)</term>
<term>Lymphome T périphérique (mortalité)</term>
<term>Lymphome T périphérique (traitement médicamenteux)</term>
<term>Pronostic</term>
<term>Radiopharmaceutiques (pharmacocinétique)</term>
<term>Répartition dans les tissus</term>
<term>Résistance aux médicaments antinéoplasiques ()</term>
<term>Stade de la tumeur</term>
<term>Taux de survie</term>
<term>Tomographie par émission de positons (utilisation)</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Fluorodeoxyglucose F18</term>
<term>Radiopharmaceuticals</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibiotics, Antineoplastic</term>
<term>Depsipeptides</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphome T périphérique</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Lymphoma, T-Cell, Peripheral</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drug Resistance, Neoplasm</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphoma, T-Cell, Peripheral</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Lymphome T périphérique</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Lymphoma, T-Cell, Peripheral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Lymphome T périphérique</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphoma, T-Cell, Peripheral</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Fluorodésoxyglucose F18</term>
<term>Radiopharmaceutiques</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphome T périphérique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibiotiques antinéoplasiques</term>
<term>Depsipeptides</term>
</keywords>
<keywords scheme="MESH" qualifier="utilisation" xml:lang="fr"><term>Tomographie par émission de positons</term>
</keywords>
<keywords scheme="MESH" qualifier="utilization" xml:lang="en"><term>Positron-Emission Tomography</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Follow-Up Studies</term>
<term>Humans</term>
<term>Neoplasm Staging</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Remission Induction</term>
<term>Survival Rate</term>
<term>Tissue Distribution</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Induction de rémission</term>
<term>Pronostic</term>
<term>Répartition dans les tissus</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Stade de la tumeur</term>
<term>Taux de survie</term>
<term>Études de suivi</term>
<term>Études prospectives</term>
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<front><div type="abstract" xml:lang="en"><p>This study examined the utility of PET scans for assessing prognosis and response to treatment in patients with relapsed/refractory PTCL receiving romidepsin. For patients with stable disease or partial response by conventional criteria, PET status better differentiated durability of response than conventional response category. Routine PET use may aid in treatment planning in patients with PTCL.</p>
</div>
</front>
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</author>
<author><name sortKey="Cang, S" uniqKey="Cang S">S Cang</name>
</author>
<author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bolden, Je" uniqKey="Bolden J">JE Bolden</name>
</author>
<author><name sortKey="Peart, Mj" uniqKey="Peart M">MJ Peart</name>
</author>
<author><name sortKey="Johnstone, Rw" uniqKey="Johnstone R">RW Johnstone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bradner, Je" uniqKey="Bradner J">JE Bradner</name>
</author>
<author><name sortKey="West, N" uniqKey="West N">N West</name>
</author>
<author><name sortKey="Grachan, Ml" uniqKey="Grachan M">ML Grachan</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Piekarz, Rl" uniqKey="Piekarz R">RL Piekarz</name>
</author>
<author><name sortKey="Frye, R" uniqKey="Frye R">R Frye</name>
</author>
<author><name sortKey="Prince, Hm" uniqKey="Prince H">HM Prince</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coiffier, B" uniqKey="Coiffier B">B Coiffier</name>
</author>
<author><name sortKey="Pro, B" uniqKey="Pro B">B Pro</name>
</author>
<author><name sortKey="Prince, Hm" uniqKey="Prince H">HM Prince</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coiffier, B" uniqKey="Coiffier B">B Coiffier</name>
</author>
<author><name sortKey="Pro, B" uniqKey="Pro B">B Pro</name>
</author>
<author><name sortKey="Prince, Hm" uniqKey="Prince H">HM Prince</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Foss, Fm" uniqKey="Foss F">FM Foss</name>
</author>
<author><name sortKey="Zinzani, Pl" uniqKey="Zinzani P">PL Zinzani</name>
</author>
<author><name sortKey="Vose, Jm" uniqKey="Vose J">JM Vose</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vose, J" uniqKey="Vose J">J Vose</name>
</author>
<author><name sortKey="Armitage, J" uniqKey="Armitage J">J Armitage</name>
</author>
<author><name sortKey="Weisenburger, D" uniqKey="Weisenburger D">D Weisenburger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Horwitz, Sm" uniqKey="Horwitz S">SM Horwitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mehta, N" uniqKey="Mehta N">N Mehta</name>
</author>
<author><name sortKey="Maragulia, Jc" uniqKey="Maragulia J">JC Maragulia</name>
</author>
<author><name sortKey="Moskowitz, A" uniqKey="Moskowitz A">A Moskowitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mak, V" uniqKey="Mak V">V Mak</name>
</author>
<author><name sortKey="Hamm, J" uniqKey="Hamm J">J Hamm</name>
</author>
<author><name sortKey="Chhanabhai, M" uniqKey="Chhanabhai M">M Chhanabhai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheson, Bd" uniqKey="Cheson B">BD Cheson</name>
</author>
<author><name sortKey="Horning, Sj" uniqKey="Horning S">SJ Horning</name>
</author>
<author><name sortKey="Coiffier, B" uniqKey="Coiffier B">B Coiffier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ansell, Sm" uniqKey="Ansell S">SM Ansell</name>
</author>
<author><name sortKey="Armitage, Jo" uniqKey="Armitage J">JO Armitage</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Juweid, Me" uniqKey="Juweid M">ME Juweid</name>
</author>
<author><name sortKey="Wiseman, Ga" uniqKey="Wiseman G">GA Wiseman</name>
</author>
<author><name sortKey="Vose, Jm" uniqKey="Vose J">JM Vose</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Cheson, Bd" uniqKey="Cheson B">BD Cheson</name>
</author>
<author><name sortKey="Pfistner, B" uniqKey="Pfistner B">B Pfistner</name>
</author>
<author><name sortKey="Juweid, Me" uniqKey="Juweid M">ME Juweid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suh, C" uniqKey="Suh C">C Suh</name>
</author>
<author><name sortKey="Kang, Yk" uniqKey="Kang Y">YK Kang</name>
</author>
<author><name sortKey="Roh, Jl" uniqKey="Roh J">JL Roh</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Pang, Cb" uniqKey="Pang C">CB Pang</name>
</author>
<author><name sortKey="Liang, R" uniqKey="Liang R">R Liang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karantanis, D" uniqKey="Karantanis D">D Karantanis</name>
</author>
<author><name sortKey="Subramaniam, Rm" uniqKey="Subramaniam R">RM Subramaniam</name>
</author>
<author><name sortKey="Peller, Pj" uniqKey="Peller P">PJ Peller</name>
</author>
</analytic>
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</author>
<author><name sortKey="Yildiz, R" uniqKey="Yildiz R">R Yildiz</name>
</author>
<author><name sortKey="Akdemir, Uo" uniqKey="Akdemir U">UO Akdemir</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Kako, S" uniqKey="Kako S">S Kako</name>
</author>
<author><name sortKey="Izutsu, K" uniqKey="Izutsu K">K Izutsu</name>
</author>
<author><name sortKey="Ota, Y" uniqKey="Ota Y">Y Ota</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bishu, S" uniqKey="Bishu S">S Bishu</name>
</author>
<author><name sortKey="Quigley, Jm" uniqKey="Quigley J">JM Quigley</name>
</author>
<author><name sortKey="Schmitz, J" uniqKey="Schmitz J">J Schmitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Hb" uniqKey="Wu H">HB Wu</name>
</author>
<author><name sortKey="Wang, Qs" uniqKey="Wang Q">QS Wang</name>
</author>
<author><name sortKey="Wang, Mf" uniqKey="Wang M">MF Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hadithi, M" uniqKey="Hadithi M">M Hadithi</name>
</author>
<author><name sortKey="Mallant, M" uniqKey="Mallant M">M Mallant</name>
</author>
<author><name sortKey="Oudejans, J" uniqKey="Oudejans J">J Oudejans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feeney, J" uniqKey="Feeney J">J Feeney</name>
</author>
<author><name sortKey="Horwitz, S" uniqKey="Horwitz S">S Horwitz</name>
</author>
<author><name sortKey="Gonen, M" uniqKey="Gonen M">M Gonen</name>
</author>
<author><name sortKey="Schoder, H" uniqKey="Schoder H">H Schoder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Casulo, C" uniqKey="Casulo C">C Casulo</name>
</author>
<author><name sortKey="Schoder, H" uniqKey="Schoder H">H Schoder</name>
</author>
<author><name sortKey="Feeney, J" uniqKey="Feeney J">J Feeney</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="O Connor, Oa" uniqKey="O Connor O">OA O'Connor</name>
</author>
<author><name sortKey="Pro, B" uniqKey="Pro B">B Pro</name>
</author>
<author><name sortKey="Pinter Brown, L" uniqKey="Pinter Brown L">L Pinter-Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pellegrini, C" uniqKey="Pellegrini C">C Pellegrini</name>
</author>
<author><name sortKey="Casadei, B" uniqKey="Casadei B">B Casadei</name>
</author>
<author><name sortKey="Derenzini, E" uniqKey="Derenzini E">E Derenzini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pro, B" uniqKey="Pro B">B Pro</name>
</author>
<author><name sortKey="Advani, Rh" uniqKey="Advani R">RH Advani</name>
</author>
<author><name sortKey="Brice, P" uniqKey="Brice P">P Brice</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cahu, X" uniqKey="Cahu X">X Cahu</name>
</author>
<author><name sortKey="Bodet Milin, C" uniqKey="Bodet Milin C">C Bodet-Milin</name>
</author>
<author><name sortKey="Brissot, E" uniqKey="Brissot E">E Brissot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meignan, M" uniqKey="Meignan M">M Meignan</name>
</author>
<author><name sortKey="Gallamini, A" uniqKey="Gallamini A">A Gallamini</name>
</author>
<author><name sortKey="Itti, E" uniqKey="Itti E">E Itti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yhim, Hy" uniqKey="Yhim H">HY Yhim</name>
</author>
<author><name sortKey="Lee, Nr" uniqKey="Lee N">NR Lee</name>
</author>
<author><name sortKey="Song, Ek" uniqKey="Song E">EK Song</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Dh" uniqKey="Yang D">DH Yang</name>
</author>
<author><name sortKey="Min, Jj" uniqKey="Min J">JJ Min</name>
</author>
<author><name sortKey="Ahn, Js" uniqKey="Ahn J">JS Ahn</name>
</author>
</analytic>
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</TEI>
<affiliations><list><country><li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>États-Unis</li>
</country>
</list>
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<name sortKey="Balser, J" sort="Balser, J" uniqKey="Balser J" first="J." last="Balser">J. Balser</name>
<name sortKey="Iyer, S P" sort="Iyer, S P" uniqKey="Iyer S" first="S. P." last="Iyer">S. P. Iyer</name>
<name sortKey="Nichols, J" sort="Nichols, J" uniqKey="Nichols J" first="J." last="Nichols">J. Nichols</name>
<name sortKey="Pinter Brown, L" sort="Pinter Brown, L" uniqKey="Pinter Brown L" first="L." last="Pinter-Brown">L. Pinter-Brown</name>
<name sortKey="Shustov, A" sort="Shustov, A" uniqKey="Shustov A" first="A." last="Shustov">A. Shustov</name>
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<name sortKey="Sokol, L" sort="Sokol, L" uniqKey="Sokol L" first="L." last="Sokol">L. Sokol</name>
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<name sortKey="Morschhauser, F" sort="Morschhauser, F" uniqKey="Morschhauser F" first="F." last="Morschhauser">F. Morschhauser</name>
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<country name="Espagne"><noRegion><name sortKey="Caballero, D" sort="Caballero, D" uniqKey="Caballero D" first="D." last="Caballero">D. Caballero</name>
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Utility of 18fluoro-deoxyglucose positron emission tomography for prognosis and response assessments in a phase 2 study of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma

Utility of 18fluoro-deoxyglucose positron emission tomography for prognosis and response assessments in a phase 2 study of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma

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